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Product Usage Notice · This product is intended strictly for research and laboratory use only. It is designated for in vitro testing and experimental purposes. Any use involving human or animal consumption is prohibited by law. All information provided on this website is for educational purposes only. This product must only be handled by licensed, qualified professionals. It is not intended for use as a drug, food, or cosmetic, and must not be misused, mislabeled, or misrepresented as such. Read full Research Use Policy →

Compound Information

Technical specifications

Molecular Profile

What Is Melanotan II?

Melanotan-2 is a cyclic synthetic analog of alpha-MSH, studied for its activity at MC1R, MC3R, MC4R, and MC5R receptors with applications in melanogenesis and melanocortin receptor signaling research.

Type: Peptide
CAS Number: 121062-08-6
Molecular Weight: 1024.18 g/mol
Amino Acids: 7 residues
Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Formula: C50H69N15O9

PubChem Database

MELANOTAN II · 2000

Melanocortin Receptor Agonists and Central Nervous System Signaling Published receptor pharmacology literature examining melanocortin receptor mechanisms. Cited for scientific context describing MC receptor activation mechanisms studied in the literature. does not provide use guidance or product claims for this research compound.

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MELANOTAN II · 2006

Effect of Melanotan [Nle4, D-Phe7]-α-MSH on MC1R-Linked Melanin Synthesis Peptides Published pharmacology literature examining melanocortin receptor-mediated pigmentation signaling. Cited for scientific context only; it does not provide use guidance or product claims for this research compound.

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MELANOTAN II · 2025

An Overview of Mechanisms of Chronic Melanocortin-1 Receptor Activation Journal of the European Academy of Dermatology and Venereology 2025 review examining melanogenesis mechanisms and melanocortin receptor biology. Cited for scientific context only; it does not provide use guidance or product claims for this research compound.

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MELANOTAN II · 2006

Melanocortin Receptor Pharmacology and MC3R/MC4R Signaling Published study examining melanocortin receptor signaling mechanisms. Cited for scientific context only; it does not provide use guidance or product claims for this research compound.

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MELANOTAN II · 1989

Superpotent α-Melanotropin Analogs: Biological Activities and Melanogenesis in Murine Melanoma Cells Molecular and Cellular Endocrinology Original characterization of Melanotan II demonstrating enhanced melanotropic potency versus native α-MSH, prolonged biological activity, and resistance to enzymatic degradation in cell-based models.

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MELANOTAN II · 2000

Concentration-Response Studies of Melanocortin Receptor Agonism Published receptor pharmacology literature examining concentration-dependent melanocortin receptor activation. Cited for scientific context only; it does not provide use guidance or product claims for this research compound.

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