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Compound Information

Technical specifications

Molecular Profile

What Is MOTS-C?

MOTS-c is a mitochondria-derived peptide encoded by a 12S rRNA open reading frame, investigated for metabolic regulation, insulin pathway markers, and exercise-associated cellular stress signaling.

Type: Peptide
CAS Number: 1627580-64-6
Molecular Weight: 2174.64 g/mol
Amino Acids: 16 residues
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Formula: C101H152N28O22S2

PubChem Database

MOTS-C · 2021

MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis Nature Communications MOTS-c enhanced physical performance across the longevity markers; in aged mice (equivalent to 65+ years), it doubled running capacity by regulating nuclear gene expression in skeletal muscle.

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MOTS-C · 2015

The Mitochondrial-Derived Peptide MOTS-c Modulates Metabolic Homeostasis Cell Metabolism Foundational study identifying MOTS-c as a novel mitochondrial-derived peptide and characterizing AMPK activation via folate cycle inhibition in diet-induced animal models. Cited for scientific context only.

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MOTS-C · 2025

Mitochondrial-Encoded Peptide MOTS-c and Pancreatic Islet Cell Senescence Pathway Research Experimental & Molecular Medicine MOTS-c modulated senescence markers in aged pancreatic islets and metabolic pathway readouts in mouse models. Cited for scientific context only; it does not provide use guidance or product claims for this research compound.

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MOTS-C · 2021

MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis Nature Communications MOTS-c levels increase with exercise, and exogenous MOTS-c administration in aged mice changed physical capacity, grip strength, gait, and thermogenesis to levels approximating young controls.

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MOTS-C · 2019

MOTS-c Peptide Regulates Adipose Homeostasis in Metabolic Dysfunction Models Journal of Molecular Medicine Animal study examining MOTS-c AMPK signaling effects on brown adipose tissue activation and metabolic pathway modulation in an ovariectomy mouse model. Cited for scientific context only.

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MOTS-C · 2018

The Mitochondrial-Derived Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress Cell Metabolism MOTS-c translocates to the nucleus under metabolic stress to directly regulate ARE-containing genes via AMPK-dependent chromatin remodeling — establishing a novel mito-nuclear communication pathway.

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