Name: TB-500 (Thymosin Beta-4)
Brand: PeptiHealth
Availability: OutOfStock

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Compound Information

Technical specifications

Molecular Profile

What Is TB-500 (Thymosin Beta-4)?

TB-500 is a synthetic analog of thymosin beta-4 fragment (Ac-SDKP and extended sequence), investigated for tissue remodeling signaling, angiogenesis, anti-inflammatory effects, and actin-sequestration properties.

Type: Peptide
CAS Number: 885340-08-9
Molecular Weight: 889.02 g/mol
Amino Acids: 17 residues
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys
Formula: C39H66N12O13

PubChem Database

TB-500 · 2004

Thymosin β4 Activates Integrin-Linked Kinase and Modulates Cardiac Cell Migration, Survival and cardiac tissue signaling Nature Thymosin β4 activated epicardial progenitor cells, inhibited myocardial stress markers, modulated vessel growth, and modulated cardiac tissue markers through integrin-linked kinase activation.

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TB-500 · 2007

Thymosin β4 Induces Adult Epicardial Progenitor Mobilization and Neovascularization Nature Thymosin β4 activated quiescent epicardial cells, modulating their migration into cardiac tissue where they facilitate coronary neovascularization and matrix signaling of myocardial tissue markers.

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TB-500 · 2015

Thymosin Beta 4 and Ocular Surface Matrix-Signaling Pathway Research Ophthalmology Published pharmacology literature describing thymosin β4 pathway research in ocular surface models, including epithelial migration, extracellular matrix signaling, and corneal surface marker modulation.

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TB-500 · 2018

RGN-259 (Thymosin β4) changes Pathway-relevant ocular surface pathway readouts in Comparison with reference compounds Scientific Reports Thymosin β4 proved equal to or more active in comparison with cyclosporine A, diquafosol, and lifitegrast in modulating mucin pathway markers, corneal integrity, and modulating inflammation.

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TB-500 · 2012

Thymosin β4: A Multi-Functional Matrix-signaling Peptide. Basic Properties and research applications Expert Opinion on Biological research literature Comprehensive review spanning three decades of Tβ4 research documenting its roles in tissue remodeling, inflammation pathway modulation, angiogenesis, and cardiac tissue signaling with a focus on translational research applications.

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TB-500 · 2006

Thymosin Beta 4 Modulates Dermal tissue remodeling via Its inflammatory pathway and Tissue-Matrix-signaling Activities Journal of Investigative Dermatology Topical and systemic Tβ4 application changed dermal tissue remodeling in aged mice, with enhanced angiogenesis, collagen deposition, and keratinocyte migration compared to controls.

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