Compound reference
5-Amino-1MQ
Metabolic Research · vial. For laboratory research use only. Not for human or veterinary consumption, diagnostic use, therapeutic use, or clinical use.
Chemistry identity
Reference identifiers
COA documentation
Lot record status
COA on file - lab confirmation pendingView Lab ReportsPublished literature
Research context
Peer-reviewed literature referencing this compound, provided for research context.
Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction2024
Babula JJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H
Diabetes, Obesity & Metabolism
In diet-induced obese mice, the NNMT inhibitor 5-amino-1-methylquinolinium (5A1MQ) limited body-weight and fat-mass gains, improved oral glucose tolerance and insulin sensitivity, and attenuated hepatic steatosis; plasma and tissue pharmacokinetics showed effective distribution to metabolically active tissues, supporting NNMT inhibition as a metabolic research target.
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice2017
Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, et al.
Biochemical Pharmacology
This study characterized the membrane permeability and selectivity of small-molecule NNMT inhibitors, showing they reduced intracellular 1-methylnicotinamide, increased NAD+ and S-adenosylmethionine, and suppressed lipogenesis in cultured adipocytes; in diet-induced obese mice a potent inhibitor reduced body weight and white-adipose mass, validating NNMT as a metabolic research target.
Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice2022
Dimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T, et al.
Scientific Reports
In diet-induced obese mice, NNMT inhibition combined with a reduced-calorie diet was associated with a distinct cecal microbiome signature (increased Lactobacillus, decreased Erysipelatoclostridium) relative to the diet change alone, linking the NNMT-inhibitor metabolic effects to gut-microbiome composition.
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