Compound reference
Epithalon
Cellular & Longevity Research · vial. For laboratory research use only. Not for human or veterinary consumption, diagnostic use, therapeutic use, or clinical use.
Chemistry identity
Reference identifiers
COA documentation
Lot record status
COA on file - lab confirmation pendingView Lab ReportsPublished literature
Research context
Peer-reviewed literature referencing this compound, provided for research context.
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity2025
Al-Dulaimi S, Thomas R, Matta S, Roberts T
Biogerontology
In human breast cancer cell lines (21NT, BT474) and normal epithelial/fibroblast cell lines, epitalon produced concentration-dependent telomere length extension, driven by hTERT/telomerase upregulation in normal cells and by activation of the ALT (Alternative Lengthening of Telomeres) pathway in cancer cell lines, as measured by qPCR and immunofluorescence.
Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development2025
Ullah S, Haider Z, Perera CD, Lee SH, Idrees M, Park S, et al.
Life sciences
In an in vitro bovine cumulus-oocyte complex and embryo-culture model, epitalon activated telomerase and was associated with improved oocyte maturation rate and post-thaw blastocyst hatching, assessed via qPCR, reactive-oxygen-species, and mitochondrial membrane potential (JC-1) assays.
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism2020
Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, et al.
Molecules (Basel, Switzerland)
In human gingival mesenchymal stem cells, the AEDG tetrapeptide (epitalon) increased expression of neurogenic-differentiation markers (Nestin, GAP43, beta-Tubulin III, Doublecortin) at the mRNA and protein level, with molecular modeling suggesting a histone-binding epigenetic mechanism underlying the gene-expression change.
Peptide promotes overcoming of the division limit in human somatic cell2004
Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD
Bulletin of experimental biology and medicine
In cultured human fetal pulmonary fibroblasts approaching replicative senescence, epithalon elongated telomeres to lengths comparable with early-passage cells and allowed the cell population to complete additional divisions beyond the limit observed in untreated control cultures.
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells2003
Khavinson VKh, Bondarev IE, Butyugov AA
Bulletin of experimental biology and medicine
In a telomerase-negative human fetal fibroblast culture model, addition of epithalon peptide induced expression of the telomerase catalytic subunit, restored measurable telomerase enzymatic activity, and produced telomere elongation, consistent with reactivation of the telomerase gene in these somatic cells.
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