Compound reference
PT-141 (Bremelanotide)
Cognitive & Neuro Research · vial. For laboratory research use only. Not for human or veterinary consumption, diagnostic use, therapeutic use, or clinical use.
Chemistry identity
Reference identifiers
COA documentation
Lot record status
COA on file - lab confirmation pendingView Lab ReportsPublished literature
Research context
Peer-reviewed literature referencing this compound, provided for research context.
Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression2024
Suzuki S, Kitanaka C, Okada M
Anticancer research
In cultured glioblastoma cell lines, bremelanotide reduced expression of the anti-apoptotic protein survivin and induced cell death at concentrations non-toxic to normal cells; effects were blocked by an MC3R/MC4R antagonist, identifying melanocortin receptor activation as a modulator of tumor-cell survival-signaling pathways in this in-vitro model.
Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin2022
Yuan XC, Tao YX
Biomolecules
Review of ligands acting at the neural melanocortin receptors MC3R and MC4R, which are concentrated in the central nervous system and central to energy-homeostasis signal transduction; bremelanotide is discussed among cyclic-peptide agonists alongside endogenous melanocortins and agouti-related peptide as pharmacological tools for probing MC3R/MC4R receptor biology.
Structural insights into ligand recognition and activation of the melanocortin-4 receptor2021
Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, et al.
Cell research
Cryo-EM structures of full-length MC4R bound to its heterotrimeric G protein and several agonists, including bremelanotide, revealed the conserved peptide-binding pocket and a receptor-subtype-specific activation mechanism, providing structural detail on how cyclic melanocortin peptides engage and activate MC4R signal transduction.
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