Compound reference
SNAP-8
Tissue & Repair Research · vial. For laboratory research use only. Not for human or veterinary consumption, diagnostic use, therapeutic use, or clinical use.
Chemistry identity
Reference identifiers
COA documentation
Lot record status
COA on file - lab confirmation pendingView Lab ReportsPublished literature
Research context
Peer-reviewed literature referencing this compound, provided for research context.
Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities2024
Shin JY, Han D, Yoon KY, Jeong DH, Park YI
Annals of dermatology
According to PubMed, this 2024 study (Shin et al., Annals of Dermatology, DOI 10.5021/ad.23.136) evaluated a dissolving hyaluronic-acid microneedle patch containing acetyl octapeptide-3 (SNAP-8) alongside L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid, applied periorbitally in 24 volunteers as an in vivo transdermal peptide-delivery model. Outcome measures were transepidermal water loss, skin elasticity, and wrinkle-depth imaging tracked over 28 days.
Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study2020
Avcil M, Akman G, Klokkers J, Jeong D, Çelik A
Journal of cosmetic dermatology
According to PubMed, this 2019 monocentric study (Avcil et al., Journal of Cosmetic Dermatology, DOI 10.1111/jocd.13009) assessed hyaluronic-acid microneedle patches loaded with acetyl octapeptide-3 (SNAP-8) in combination with other bioactive ingredients, using instrumental skin-property measurement (hydration, dermal density, thickness, fine-line depth) as an in vivo biophysical model for multi-peptide topical delivery over a 12-week period.
Identification of SNARE complex modulators that inhibit exocytosis from an alpha-helix-constrained combinatorial library2003
Blanes-Mira C, Pastor MT, Valera E, Fernández-Ballester G, Merino JM, Gutierrez LM, et al.
The Biochemical journal
According to PubMed, this 2003 study (Blanes-Mira et al., Biochemical Journal, DOI 10.1042/BJ20030509) screened an alpha-helix-constrained combinatorial peptide library against detergent-permeabilized bovine chromaffin cells and rat hippocampal neuron cultures, identifying peptides that block SNARE-core-complex assembly and inhibit Ca2+-evoked catecholamine and glutamate release. This established the in vitro exocytosis-inhibition pharmacology model used to characterize SNARE-mimetic peptides in the same structural class as SNAP-8.
A synthetic hexapeptide (Argireline) with antiwrinkle activity2002
Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, et al.
International journal of cosmetic science
According to PubMed, this 2002 study (Blanes-Mira et al., International Journal of Cosmetic Science, DOI 10.1046/j.1467-2494.2002.00153.x) characterized Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 (Argireline), the parent hexapeptide sequence from which SNAP-8 was later derived by C-terminal extension. In vitro exocytosis assays showed the hexapeptide interfered with SNARE-complex formation and stability and inhibited neurotransmitter release with potency comparable to botulinum neurotoxin type A, establishing the SNARE-inhibition mechanism this peptide class is researched for.
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This product is intended strictly for research and laboratory use only. It is designated for in vitro testing and experimental purposes. Any use involving human or animal consumption is prohibited by law. All information provided on this website is for educational purposes only. This product must only be handled by licensed, qualified professionals. It is not intended for use as a drug, food, or cosmetic, and must not be misused, mislabeled, or misrepresented as such.