Compound reference
Vip
Cognitive & Neuro Research · vial. For laboratory research use only. Not for human or veterinary consumption, diagnostic use, therapeutic use, or clinical use.
Chemistry identity
Reference identifiers
COA documentation
Lot record status
COA per lot - on requestView Lab ReportsPublished literature
Research context
Peer-reviewed literature referencing this compound, provided for research context.
Hypothalamic clock governs circadian pain2026
Wei HR, Lou Q, Li LX, Tang L, Wu RJ, Li HY, et al.
Science (New York, N.Y.)
In a mouse model of neuropathic pain, this Science study identified a circuit in which VIP-expressing neurons in the suprachiasmatic nucleus (SCN) show daily oscillations in activity that signal through the paraventricular nucleus to the periaqueductal gray, driving circadian changes in nociceptive threshold across the light/dark cycle.
A GABAergic network from AVP- to VIP-neurons in the suprachiasmatic nucleus sets the timing of circadian behavior rhythms2026
Peng Y, Tsuno Y, Maejima T, Wang M, Jung J, Matsui A, et al.
PLoS biology
Using mouse suprachiasmatic-nucleus brain slices and in vivo calcium imaging, this PLoS Biology study mapped a GABAergic circuit from arginine-vasopressin neurons onto VIP neurons, showing that GABA release and GABA-A receptor signaling within VIP neurons shape the timing of circadian locomotor activity rhythms.
Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1 receptors2014
Cunha-Reis D, Aidil-Carvalho Mde F, Ribeiro JA
Hippocampus
In rat hippocampal slice preparations, this study found that endogenous VIP acting through VPAC1 receptors inhibits long-term depression and depotentiation of CA1 synaptic transmission via a GABAergic mechanism, identifying VPAC1 receptor signaling as relevant to models of hippocampal synaptic plasticity.
Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release2014
Nunan R, Sivasathiaseelan H, Khan D, Zaben M, Gray W
Glia
In rat hippocampal cell cultures, VIP signaling through microglial VPAC1 receptors triggered IL-4 release that enhanced proliferation of neural stem/progenitor cells, describing a neuro-immune mechanism linking VIP receptor activation to hippocampal precursor-cell proliferation in vitro.
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